Mannitol 69-65-8 ycgcsale56(at)yccreate.comALIAS:DL-Mannitol; AI3-19511; Hexahydroxyhexane; Mannidex 16700; NSC 9256; D-Mannitol; D-(-)-Mannitol; hexitol; L-altritoCAS NO. :69-65-8Formula:C6H14O6Molecular Weight:182.17Product D-mannitol. Calculated on dry goods, containing C6H14O6 98.0 to 102.0%.【Properties】 This product is a white crystalline powder; odorless, sweet.This product is soluble in water, almost insoluble in ethanol or ether.The melting point of this product melting point (Appendix Ⅵ C) is 166 ~ 170 ℃.[Identification] (1) To about 0.5g, set in a test tube, add acetyl chloride 3ml, the slowly dropping pyridine 0.5ml, with theDropwise with shaking, as soon as the completion of the reaction, attention to the solution was transferred to another tube, cooled with ice, and the precipitated crystals were filtered,Washed with ether and 10ml the displacement test tube, add ether 15ml, set a warm bath heated to dissolve, hot poured take etherLiquid volatilized ether, white crystals (if necessary, then recrystallized from 1 time), after drying, according to the determination (Appendix VI C),The melting point of 120 ~ 125 ℃.(2) take the goods saturated aqueous solution 1ml, 0.5ml, plus ferric chloride test solution and sodium hydroxide solution that is generatedThe yellow-brown precipitate was shaken not disappear; brown solution was dissolved into an excess of sodium hydroxide solution was added dropwise.The infrared absorption spectrum of (3) of this product should be in control of the map (spectral set of 84).[Check] acidity to take this product 5.0g, plus new boiling 50ml of cold water is dissolved, add phenolphthalein indicator solution 3 dropsSodium hydroxide solution (0.02mol / L) 0.30ml, should substantially pink.Clarity and color of solution 1.5g 10ml water dissolved, the solution should be clear and colorless to take this product; such as explicit muddyCompared with the 1st turbidity standard solution (Appendix Ⅸ B) shall not be thicker.Chloride 1.0g, take this product according to inspection (Appendix Ⅷ A), with standard sodium chloride solution 3.0ml made onControl solution comparison, not thicker (0.003%).Sulfate to take this product 2.0g, according to inspection (Appendix Ⅷ B) with standard potassium sulfate solution 2.0ml made controlLiquid comparison, not thicker (0.01%).Oxalate to take this product 1.0g, add water 6ml, heating dissolved, let cool, add 3 drops of ammonia solution with calcium chloride test solution1ml, shaken, heated in a water bath for 15 minutes, remove the cool; such as the occurrence of turbidity of oxalic acid and sodium oxalate solutionSodium 0.1523g, set 1000ml LiangPing, dissolved in water and diluted to the mark, shake. 1ml equivalent to 0.1mgOxalate (C2O4)] 2.0ml of the control solution is made by the same method comparison, not thicker (0.02%).Drying of this product, dried at 105 ℃ to constant weight, less weight loss should not exceed 0.5% (Appendix Ⅷ L).The ignition residue should not exceed 0.1% (Appendix VIII N).Heavy metal to take this product 2.0g, dissolved plus water 23ml vinegar salt buffer (pH3.5) 2ml, according to inspection (Appendix Ⅷ H first law), containing heavy metals should not exceed ten millionths.Arsenic salt to take this product 1.0g, 10ml water to dissolve, add dilute sulfuric acid the 5ml and potassium bromide bromine test solution 0.5ml, home waterBath and heated for 20 minutes, so to maintain a slight excess of the presence of bromine (if necessary, was added dropwise the KBr bromine test solution), and added at any time.Evaporation of water, cool, add hydrochloric 5ml amount of water to make into a 28ml, according to inspection (Appendix Ⅷ J first method) should beCompliance (0.0002%).Determination of take the product of about 0.2 g, accurately weighed, set 250ml volumetric flask, add water to dissolve and dilute to the tab title # p # # e #Scale, shake; precise amount of 10ml, set iodine bottle, Precision added sodium (potassium) solution [sulfuric acid solution (1→ 20) 90ml sodium periodate (potassium) solution (2.3 → 1000) made 110ml mixed] 50ml, heated on a water bath 15Minutes, let cool, add 10 ml of potassium iodide test solution, Mesa, for 5 minutes, titrated with sodium thiosulfate solution (0.05mol / L) Titration to near the end, add the starch indicator solution 1ml continue titration to the disappearance of the blue, and the results of titration with an emptyWhite test correction. Each 1 ml of sodium thiosulfate titration solution (0.05mol / L) is equivalent to 0.9109mg of C6H14O6.【Category】 dehydration, diuretics.[Storage] Sealed,.[Preparations] mannitol injectionLisa yangE-mail: ycgcsale56(at)yccreate.comPhone: 86-027-88085967Mobile: 86-18062666846QQ:2355327044Skype：agneschem
